Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. 8(7):377-85.

HTB2 histone H2B [] Gene ID: 852284, updated on 29-Oct-2016. This gene is found in the large histone gene cluster on chromosome 6. The tight control of nucleosomal organization is critical for chromatin processes like transcription, DNA replication, repair and recombination [ 2 – 4 ]. H2B forms a (H2A-H2B)-2 tetramer. Plasmid H2B-GFP from Dr. Geoff Wahl's lab contains the insert Human histone H2B and is published in Curr Biol. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. These modifications affect the structural and functional organization of chromatin, and the majority of them are found outside the globular domain of the nucleosome where amino acidresidues are more accessible.


The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Histone H2B H2A is often overlooked, but H2B often forgotten completely.

This gene is intronless and encodes a member of the histone H2B family. 1998 Mar 26. Hyperacetylation of histone tails helps There are sixteen variants of histone H2B found in humans, thirteen of which are Histone H2B isoforms interact differently with other Histone H2B is modified by a combination of several types of post-translational modifications. Summary.
A role for the H2B nucleosome acidic patch in recruitment of histone modification machinery and maintenance of transcriptional integrity. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes.

GeneRIFs: Gene References Into Functions. … The basic subunit of chromatin is the nucleosome, which contains an octamer core of histones H2A, H2B, H3 and H4 wrapped around 147bp of DNA [ 1 ]. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Summary. More than 20 requests

H2BC21 H2B clustered histone 21 [ (human)] Gene ID: 8349, updated on 7-Jun-2020. Acetylation, phosphorylation, and ubiquitination are the most common and most studied modifications … Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. Possible modifications include acetylation, methylation, phosphorylation, ubiquitination, and sumoylation. This plasmid is available through Addgene.

Histone H2B is modified by a combination of several types of post-translational modifications. … Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BC gene. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Histone H2B is a lightweight structural protein made of 126 Two copies of histone H2B come together with two copies each of Acetylation and ubiquitination are examples of two post-translational modifications that affect the function of histone H2B in particular ways. The H2B-GFP system allows the high-resolution imaging of chromosomes, including DMs, without compromising nuclear and chromosomal structures and has revealed the distinctive clustering behavior of DMs in mitotic cells which contributes to their asymmetric distribution to daughter cells. This tetramer and it’s component dimers are easily exchanged in and out of the nucleosome compared to H3 and H4, meaning that the modifications on H2A and H2B are less likely to be maintained in chromatin (Kimura and Cook, 2001).