Giants vs. Bills: 6 things to know about Week 2. (AP Photo/David Duprey)New York Giants' Kawika Mitchell (55) celebrates his interception for a touchdown during the second half of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo)Joe Danelo of the New York Giants follows through, left, as his kick sails over the outstretched arms of Buffalo Bills players to win Monday, Aug. 29, 1977 exhibition game 24-21 in sudden death overtime in East Rutherford, N.J.

Julio Cortez David Duprey Julio Cortez Week 2 Buffalo Bills (1-0 SU, 1-0 ATS) vs New York Giants (0-1 SU, 0-1 ATS). The Giants defeated the Buffalo Bills, 20-19.

All Rights Reserved. (AP Photo/Bill Haber)Members of the New York Giants and the Buffalo Bill pray together in a circle as they surrounded by members of the media after the Super Bowl in Tampa Sunday, Jan. 27, 1991. (AP Photo/David Duprey)New York Giants' Brandon Jacobs (27) runs against the Buffalo Bills during the second half of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. David Duprey Of course, the Giants hold the postseason advantage. (AP Photo/Derek Gee)New York Giants cornerback Corey Webster, right, celebrates his touchdown with teammate safety James Butler, left, after a 34-yard interception against the Buffalo Bills during the second half of an NFL football game in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. The two teams have met each other 13 times, with the Buffalo Bills winning 8 games and the Green Bay Packers winning 5 games. With Parcells is Carl Banks. New York won 38-21. (AP Photo/Derek Gee)Buffalo Bills' Marshawn Lynch (23) is tackled by New York Giants' Antonio Pierce (58) and Aaron Ross (31) during the first quarter of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Don Heupel)New York Giants' Brandon Jacobs (27) scores a touchdown under pressure from Buffalo Bills' John DiGiorgio (52) during the second quarter of their NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Craig Fujii)New York Giants head coach Bill Parcells shows off the Super Bowl trophy after his team beat the Buffalo Bills 20-19 in Tampa, Fl., Jan. 28, 1991. Bill Kostroun

The Giants won 38-21. Julio Cortez Julio Cortez David Duprey (AP Photo/Bill Waugh)Buffalo Bills kicker Scott Norwood (11) walks off the field in dejection after missing a 47-yard field goal on the last play of the game, clinching a 20-19 victory for the New York Giants in Super Bowl XXV in Tampa, Fla., Jan. 27, 1991. The Bills and the Giants have played against each other a total of 13 times.

(AP Photo/Bill Kostroun)New York Giants running back Ahmad Bradshaw (44) runs past Buffalo Bills cornerback Drayton Florence (29) during the first quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)New York Giants wide receiver Rueben Randle (82) reacts after scoring a touchdown on a pass from quarterback Eli Manning as Buffalo Bills cornerback Stephon Gilmore, left, and strong safety Bacarri Rambo look on during the first half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)New York Giants running back Rashad Jennings, right, looks at Buffalo Bills cornerback Ronald Darby, left, as he scores on a touchdown run during the second half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Gary Wiepert)New York Giants quarterback Eli Manning (10) talks to his teammates during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)Photos from the career of two-time Super Bowl MVP quarterback Eli ManningHere is a photo from every one of Eli Manning's starts over his 16-year careerView photos of the first pair of brothers to play quarterback in a Super Bowl.View photos of Giants who have been tagged in the past.The Giants remember the legacy of Del Shofner, one of the NFL's top receivers of his time.We take a look at past compensatory draft picks by the New York Giants.

The New York Giants (0-1) host the Buffalo Bills (1-0) at MetLife Stadium in the Giants’ 2019 home opener.The Giants are coming off a disappointing loss in Week 1 down in Dallas, while the Bills will be returning to the same venue they played in last week when they came back to beat the Jets, 17-16.Here are six things to know about this week’s matchup:This will be the 13th time since the 1970 merger the Giants have played the Bills in the regular season. Julio Cortez Gary Wiepert

Giants' Reyna Thompson, right, celebrates as Bills holder Frank Reich (14) also leaves the field.